Propionic Acidemia
Propionic Acidemia is a rare metabolic disorder characterized by deficiency of propionyl CoA carboxylase, an enzyme involved in the breakdown (catabolism) of the chemical "building blocks" (amino acids) of certain proteins. Symptoms most commonly become apparent during the first weeks of life and may include abnormally diminished muscle tone (hypotonia), poor feeding, vomiting, listlessness (lethargy), excessive loss of fluids from bodily tissues (dehydration), and episodes of uncontrolled electrical activity in the brain (seizures). Without appropriate treatment, coma and potentially life-threatening complications may result. In rare cases, the condition may become apparent later during infancy and may be associated with less severe symptoms and findings. Propionic Acidemia is inherited as an autosomal recessive trait
|
Remedy |
Characteristics Symptoms |
Patient Worse by |
Patient Better by |
| Nux Vomica | Rather thin, spare, quick, active, nervous, and
irritable Does a good deal of mental work; has mental strains and leads a sedentary life, found in prolonged office work, overstudy, and close application to business, with its cares and anxieties. Seeks stimulants, coffee, wine, possibly in excess; or, again, he hopes to quiet his excitement, by indulging in the sedative effects of tobacco, if not really a victim, to the seductive drugs, like opium, etc Takes preferably rich and stimulating food; wine and women play their part to make him forget the close application of the day Pre-eminently a male remedy Irritable, nervous system, hypersensitive and over-impressionable Convulsions, with consciousness; worse, touch, moving Zealous fiery temperament Easily chilled, avoid open air, etc Always seems to be out of tune; inharmonious spasmodic action Sour taste, and nausea in the morning, after eating Sour, bitter eructations Nausea and vomiting, with much retching Desire for stimulants Loves fats and tolerates them well Difficult belching of gas Wants to vomit, but cannot Frequent ineffectual desire for stools, or passing but small quantities at each attempt Frequent calls to urinate; little and often Easily excited desire Menses too early, lasts too long; always irregular, blood black with faint spells Cannot sleep after 3 am until towards morning; awakes feeling wretchedly Drowsy after meals, and in early evening Dreams full of bustle and hurry |
Morning Mental exertion After eating Touch Spices Stimulants Narcotics Dry weather Cold |
From a nap, if allowed to finish it In evening While at rest In damp, wet weather Strong pressure |
| Conium Maculatum | Difficult gait, trembling, sudden loss of strength
while walking, painful stiffness of legs. etc Debility General feeling as if bruised by blows Great debility in the morning in bed Weakness of body and mind, trembling, and palpitation Terrible nausea, acrid heartburn and acid eructations; worse on going to bed Painful spasms of the stomach Amelioration from eating and aggravation a few hours after meals; acidity and burning; painful spot the level of the sternum Tremulous weakness after every stool Much difficulty in voiding; it flows and stops again Sexual desire increased; power decreased Menses delayed and scanty; parts sensitive |
Lying down Turning or rising in bed Celibacy Before and during menses From taking cold Bodily or mental exertion |
While fasting In the dark From letting limbs hang down Motion and pressure |
| Digitalis | Pulse is weak, irregular, intermittent,
abnormally slow Slow pulse in recumbent posture, but irregular and dicrotic on sitting up Faint, as if dying Bluish appearance of face Prostration from slight exertion Collapse Sweet taste with constant ptyalism Excessive nausea, not relieved by vomiting Faintness, great weakness in stomach Faintness and vomiting from motion Discomfort, even after a small quantity of food, or from mere sight or smell Tenderness of epigastrium Copious salivation White, chalk-like, ashy, pasty stools Nightly emission, with great weakness of genitals after coitus Starts from sleep in alarm that he is falling from a height |
When sitting erect After meals and music |
When stomach is empty In open air |
| Ferrum Metallicum | Best adapted to young weakly persons, anæmic and
chlorotic, with pseudo-plethora, who flush easily; cold extremities; over
sensitiveness; worse after any active effort Weakness from mere speaking or walking though looking strong Pallor of skin, mucous membranes, face, alternating with flushes Orgasms of blood to face, chest, head, lungs, etc. Irregular distribution of blood. Muscles flabby and relaxed Voracious appetite, or absolute loss of appetite Loathing of sour things Attempts to eat bring on diarrha Spits up food by the mouthful Eructations of food after eating, without nausea Nausea and vomiting after eating Vomiting immediately after eating Vomiting after midnight Intolerance of eggs Distention and pressure in the stomach after eating Heat and burning in stomach Stool undigested, at night, while eating or drinking, painless Urine involuntary; worse daytime Menses remit a day or two, and then return; too early, too profuse, last too long; pale, watery |
While sweating While sitting still After cold washing and overheating Midnight |
Walking slowly about After rising |
| Gelsemium | General prostration Dizziness, drowsiness, dullness, and trembling Slow pulse, tired feeling, mental apathy Muscular weakness Complete relaxation and prostration. Lack of muscular co-ordination General depression from heat of sun Sensitive to a falling barometer; cold and dampness brings on many complaints Children fear falling, grab nurse or crib Sluggish circulation Putrid taste and breath No thirst Urine profuse, clear, watery, with chilliness and tremulousness Hysteric convulsions Cannot get fully to sleep |
Damp weather Fog Before a thunderstorm Emotion, or excitement Bad news Tobacco-smoking When thinking of his ailments At 10 am |
Bending forward By profuse urination Open air Continued motion Stimulants |
| Phosphorus | Tall, slender persons, narrow chested, with thin,
transparent skin, weakened by loss of animal fluids, with great nervous
debility, emaciation, amative tendencies Great susceptibility to external impressions, to light, sound, odors, touch, electrical changes, thunder-storms Suddenness of symptoms, sudden prostration, faints, sweats, shooting pains, etc Thirst for very cold water Hunger soon after eating Sour taste and sour eructations after every meal Belching large quantities of wind, after eating Throws up ingesta by the mouthfuls Very fetid stools and flatus; long, narrow, hard, like a dog's; difficult to expel Desire for stool on lying on, left side Great weakness after stool Lack of power; irresistible desire; involuntary emissions, with lascivious dreams Menses too early and scanty-not profuse, but last too long Leucorrha profuse, smarting, corrosive, instead of menses Great drowsiness, especially after meals Vivid dreams of fire; of hæmorrhage; lascivious dreams Goes to sleep late and awakens weak Short naps and frequent wakings |
Touch Physical or mental exertion Twilight Warm food or drink Change of weather From getting wet in hot weather Evening Lying on left or painful side During a thunder-storm Ascending stairs. |
In dark Lying on right side Cold food Cold Open air Washing with cold water Sleep |
| Pulsatilla | Pre-eminently a female remedy, especially for mild,
gentle, yielding disposition Sad, crying readily; weeps when talking; changeable, contradictory Seeks the open air; always feels better there, even though he is chilly Symptoms ever changing Thirstless, peevish, and chilly Great sensitiveness Wants the head high; feels uncomfortable with only one pillow Lies with hands above head Greasy taste Dry mouth, without thirst; wants it washed frequently; frequently licks the dry lips Offensive odor from mouth Food, especially bread, tastes bitter Much sweet saliva Alternations of taste, bitter, bilious, greasy, salty, foul Loss of taste Desire for tonics Averse to fat food, warm food, and drink Eructations; taste of food remains a long time; after ices, fruits, pasty Bitter taste, diminished taste of all food Flatulence Dislikes butter Heartburn Thirstlessness Vomiting of food eaten long before Gnawing, hungry feeling Water brash, with foul taste in the morning No two stools alike Two or three normal stools daily Increased desire; worse when lying down Tardy menses; too late, scanty, thick, dark, clotted, changeable, intermittent Leucorrha acrid, burning, creamy Wide awake in the evening; first sleep restless Wakes languid, unrefreshed Irresistible sleepiness in afternoon |
From heat, rich fat food After eating Towards evening Warm room Lying on left or on painless side When allowing feet to hang down |
Open air Motion Cold applications Cold food and drinks, though not thirsty |
| Mercurius | Tremors everywhere Weakness with ebullitions and tremblings from least exertion Complaints increase with the sweat and rest; all associated with a great deal of weariness, prostration, and trembling A human "thermometer"; sensitive to heat and cold Breath, excretions and body smell foul Tendency to formation of pus, which is thin, greenish, putrid; streaked with thin blood Sweetish metallic taste Salivary secretions greatly increased; bloody and viscid Saliva fetid, coppery Great thirst, with moist mouth Putrid eructations Intense thirst for cold drinks Urine dark, scanty, bloody, albuminous Menses profuse, with abdominal pains Leucorrha excoriating, greenish and bloody; sensation of rawness in parts General tendency to free perspiration, but patient is not relieved thereby. |
At night Wet, damp weather Lying on right side Perspiring Warm room and warm bed |
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| Natrum Muriaticum | Great debility; most weakness felt in the morning
in bed Coldness Great liability to take cold Dry mucous membranes Constrictive sensation throughout the body Great weakness and weariness Oversensitive to all sorts of influences Hungry, yet loose flesh Heartburn, with palpitation Unquenchable thirst Sweats while eating Craving for salt Aversion to bread, to anything slimy, like oysters, fats Has to wait a long time for it to pass if others are present Menses irregular; usually profuse Leucorrha acrid, watery Sleepy in forenoon Nervous jerking during sleep Dreams of robbers |
Noise Music Warm room Lying down About 10 a m At seashore Mental exertion Consolation Heat Talking |
Open air Cold bathing Going without regular meals Lying on right side Pressure against back Tight clothing |
| Sepia | Weakness, yellow complexion, bearing-down
sensation, especially in women, upon whose organism it has most pronounced
effect Upward tendency of its symptoms Easy fainting "Ball" sensation in inner parts Acts best on brunettes All pains are from below up. Feels cold even in warm room Taste salty, putrid Everything tastes too salty Nausea in morning before eating Disposition to vomit after eating Burning in pit of stomach Longing for vinegar, acids, and pickles Worse, after milk, especially when boiled Acid dyspepsia with bloated abdomen, sour eructations Loathes fat Red, adhesive, sand in urine Leucorrha yellow, greenish; with much itching |
Forenoons and evenings Washing Laundry-work Dampness Left side After sweat Cold air Before thunder-storm |
By exercise Pressure Warmth of bed Hot applications Drawing limbs up Cold bathing After sleep |
| Aurum Metallicum | Hopeless, despondent, and great desire to commit
suicide; every opportunity is sought for self-destruction Taste putrid or bitter Appetite and thirst increased, with qualmishness Burning at stomach and hot eructations Urine turbid, like buttermilk, with thick sediment Sleepless; sobs aloud in sleep Frightful dreams |
In cold weather When getting cold Many complaints come on only in winter From sunset to sunrise |
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| Baryta Carbonica | Specially indicated in infancy and old age;
this remedy brings aid to scrofulous children, especially if they are
backward mentally and physically, are dwarfish, do not grow and develop,
have scrofulous ophthalmia, swollen abdomen, take cold easily, and then
always have swollen tonsil Very sensitive to cold Offensive foot-sweats very weak and weary, must sit or lie down or lean on something Very averse to meeting strangers Water brash, hiccough, and eructation, which relieves pressure as of a stone Hungry, but refuses food Pain and weight immediately after a meal, with epigastric tenderness Habitual colic, with hunger, but food is refused Constipation, with hard, knotty stools Diminished desire and premature impotence Menses scanty Talking in sleep; awakens frequently; feels too hot Twitching during sleep |
While thinking of symptoms From washing Lying on painful side After warm food |
Walking in open air |
| Zincum Metallicum | Defective vitality
Twitchings Convulsions, with pale face and no heat. Trembling, convulsive twitching and fidgety feet Bloody taste Hiccough, nausea, vomiting of bitter mucus Burning in stomach, heartburn from sweet things Cannot stand smallest quantity of wine Ravenous hunger about 11 am Great greediness when eating; cannot eat fast enough Atonic dyspepsia, feeling as if stomach were collapsed Griping after eating Can only void urine when sitting bent backwards Involuntary urination when walking, coughing or sneezing Erections violent Menses too late, suppressed; menses flow more at night Cries out during sleep; body jerks; wakes frightened, stared Nervous motion of feet when asleep Loud screaming out at night in sleep without being aware of it |
At menstrual period From touch Between 5 to 7 pm After dinner From wine |
While eating Discharges Appearance of eruptions |
| Ruta | All parts of the body are painful, as if bruised Feeling of intense lassitude, weakness and despair Gastralgia of aching, gnawing character Constant urging to urinate, feels bladder full |
Lying down From cold, wet weather |